Part 3: DNA Design Challenge

3.1.     Choose your protein.

Gene: GFP

MSKGEELFTGVVPILVELDGDVNGQKFSVSGEGEGDATYGKLTL KFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFYKD DGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKMEYNYNSHNVYIMADKPKNG IKVNFKIRHNIKDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHM ILLEFVTAAGITHGMDELYK

3.2.     Reverse Translate: Protein (amino acid) sequence to DNA (nucleotide) sequence.

DNA:

atgagcaaaggcgaagaactgtttaccggcgtggtgccgattctggtggaactggatggc gatgtgaacggccagaaatttagcgtgagcggcgaaggcgaaggcgatgcgacctatggc aaactgaccctgaaatttatttgcaccaccggcaaactgccggtgccgtggccgaccctg gtgaccacctttagctatggcgtgcagtgctttagccgctatccggatcatatgaaacag catgatttttttaaaagcgcgatgccggaaggctatgtgcaggaacgcaccattttttat aaagatgatggcaactataaaacccgcgcggaagtgaaatttgaaggcgataccctggtg aaccgcattgaactgaaaggcattgattttaaagaagatggcaacattctgggccataaa atggaatataactataacagccataacgtgtatattatggcggataaaccgaaaaacggc attaaagtgaactttaaaattcgccataacattaaagatggcagcgtgcagctggcggat cattatcagcagaacaccccgattggcgatggcccggtgctgctgccggataaccattat ctgagcacccagagcgcgctgagcaaagatccgaacgaaaaacgcgatcatatgattctg ctggaatttgtgaccgcggcgggcattacccatggcatggatgaactgtataaa

3.3.     Codon optimization.

Optimized for E. Coli

atgagcaaaggcgaagaactgtttaccggcgtggtgccgattctggtggaactggatggc

gatgtgaacggccagaaatttagcgtgagcggcgaaggcgaaggcgatgcgacctatggc

aaactgaccctgaaatttatttgcaccaccggcaaactgccggtgccgtggccgaccctg

gtgaccacctttagctatggcgtgcagtgctttagccgctatccggatcatatgaaacag

catgatttttttaaaagcgcgatgccggaaggctatgtgcaggaacgcaccattttttat

aaagatgatggcaactataaaacccgcgcggaagtgaaatttgaaggcgataccctggtg

aaccgcattgaactgaaaggcattgattttaaagaagatggcaacattctgggccataaa

atggaatataactataacagccataacgtgtatattatggcggataaaccgaaaaacggc

attaaagtgaactttaaaattcgccataacattaaagatggcagcgtgcagctggcggat

cattatcagcagaacaccccgattggcgatggcccggtgctgctgccggataaccattat

ctgagcacccagagcgcgctgagcaaagatccgaacgaaaaacgcgatcatatgattctg