• Write a 1-page proposal (bullet points or short paragraphs) describing:
  • Which tools/approaches from recitation you propose using (e.g., “Use Protein Language Models to do in silico mutagenesis, then AlphaFold-Multimer to check complexes.”).
  • Why you think those tools might help solve your chosen sub-problem.
  • One or two potential pitfalls (e.g., “We lack enough training data on phage–bacteria interactions.”).
  • Include a schematic of your pipeline

We propose to use ML based directed evolution to increase the toxicity of the lysis protein by making it toxic against bacteria with the P330Q mutation.